The Minister of Health Government of Sindh is Chairman of Board of Governors, Secretary Health Government of Sindh is Vice Chairman of Board of Governors and Director JIMS is Secretary of Board of Governors. The total number of BoG members are 11 now as per amendment in ACT dated 12th April, 2017 the composition of members of Board of Governors is as under:
| 1. | Minister Health Government of Sindh | Chairman |
| 2. | Member of Provincial Assembly of the constituency | Member |
| 3. | Secretary GoS Health Department | Member |
| 4. | Commissioner of the Larkano Division or in his absence the Deputy Commissioner Jacobabad | Member |
| 5. | Professor Jan Muhammad Memon | Member |
| 6. | Officer Commanding, Pakistan Air Force, Shahbaz Base Jacobabad or his representative not below the rank of Group Captain | Member |
| 7. | Mir Aijaz Hussain Jakhrani (Reputed citizen) | Member |
| 8. | Chairman, District Council Jacobabad | Member |
| 9. | One representative of USAID | Member |
| 10. | One nominee of Academic Council | Member |
| 11. | Director Of JIMS, Jacobabad | Member/Secretary |
